Design, Synthesis and Antitubercular Activity of Certain Nicotinic Acid Hydrazides
نویسندگان
چکیده
منابع مشابه
Design, synthesis and antitubercular activity of certain nicotinic Acid hydrazides.
Three series of 6-aryl-2-methylnicotinohydrazides 4a-i, N'-arylidene-6-(4-bromophenyl)-2-methylnicotino hydrazides 7a-f, and N'-(un/substituted 2-oxoindolin-3-ylidene)-6-(4-fluorophenyl)-2-methylnicotinohydrazides 8a-c were synthesized and evaluated for their potential in vitro antimycobacterial activity against M. tuberculosis. The results showed that isatin hydrazides 8a-c are remarkably more...
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Recent studies have indicated that 1, 4-dihydropyridine-3, 5-dicarboxamidederivativesshow significant anti-tubercular activity. In this research, new derivatives of 1, 4-dihydropyridine were designed and synthesized using Hantzsch condensation in which dicyclohexyl and different dicyclohexylcarbamoylwere substituted at C-3 and C-5 positions of the DHP ring.In addition, 4 (5)-chloro-2-methyl-5 (...
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Knowledge of the accessory growth factors concerned in the physiology of lactose-fermenting yeasts was needed in an investigation of fermentation that was being conducted by the Bureau of Dairy Industry. Since information on nicotinic acid requirements for the growth of yeasts not fermenting lactose was at best fragmentary and incomplete and information on lactose-fermenting yeasts was complete...
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Nicotinic acid containing pyridine nucleus having side chain at third position gives the significant effect on toxicity to the insects. Therefore, we have reported the synthesis of some nicotinic acid derivatives and their insecticidal activities. The strategy employed for the synthesis of desired nicotinic acid derivatives involved esterification of nicotinic acid. The methyl nicotinate get de...
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ژورنال
عنوان ژورنال: Molecules
سال: 2015
ISSN: 1420-3049
DOI: 10.3390/molecules20058800